The King is Dead - Long Live the King.
The Game is bigger than any of the players.
I think either Bunk or McNaulty end up dead (as per the prequels) but either way McNaulty and the reporter are through.
Bubs gains a leg up and a fresh start by being authentic with his reporter bud and getting out of the game altogether.
Slim rallies some remnants of the co-op and they take Marlo down with snoop dead and chris locked up. I want michael to be in on that but I fear he wont make it.
Carcetti fucks his career trying to juggle all sides to his advantage.
Clay wiggles out once again by feeding Lester new info.
Dukie takes Bub's place on the row.
Daniels floats to the top as Chief.
Gus quits but takes the paper's executives down with him.

I hope I'm wrong on half of this but thats how it looks from here.